Peer-Reviewed Publications
1. Jang H, Kim S, Lee JM, Oh YS, Park SM, Kim SR. Montelukast treatment protects nigral dopaminergic neurons against microglial activation in the 6-hydroxydopamine mouse model of Parkinson's disease. Neuroreport. 2017 Feb 7. doi: 10.1097/WNR.0000000000000740. [Epub ahead of print]
2. Shrestha S, Kim SY, Yun YJ, Kim JK, Lee JM, Shin M, Song DK, Hong CW. Retinoic acid induces hypersegmentation and enhances cytotoxicity of neutrophils against cancer cells. Immunol Lett. 2017 Feb;182:24-29. doi: 10.1016/j.imlet.2017.01.001.
3. Lee JM. Transcriptional coordination of hepatic autophagy by nutrient-sensing nuclear receptor PPARα and FXR. Ann Pediatr Endocrinol Metab. 2016 Dec;21(4):193-198. doi: 10.6065/apem.2016.21.4.193. Review.
4. Wu N, Kim KH, Zhou Y, Lee JM, Kettner NM, Mamrosh JL, Choi S, Fu L, Moore DD. Small Heterodimer Partner (NR0B2) Coordinates Nutrient Signaling and the Circadian Clock in Mice. Mol Endocrinol. 2016 Sep;30(9):988-95. doi: 10.1210/me.2015-1295. Epub 2016 Jul 18.
5. Kim KH, Lee JM, Zhou Y, Harpavat S, and Moore DD. Glucocorticoids Have Opposing Effects on Liver Fibrosis in Hepatic Stellate and Immune Cells. Mol Endocrinol. 2016 Aug;30(8):905-16. doi: 10.1210/me.2016-1029. Epub 2016 Jun 29.
6. Wagner M, Choi S, Panzitt K, Mamrosh JL, Lee JM, Zaufel A, Xiao R, Wooton-Kee R, Ståhlman M, Newgard CB, Borén J, Moore DD. Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism. Hepatology. 2015 Aug 12. doi: 10.1002/hep.28124. [Epub ahead of print]
7. Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, and Moore DD. Nutrient-sensing nuclear receptors coordinate autophagy. Nature. 2014 Dec 4; 516(7529): 112-5. Epub 2014 Nov 12.
Comment in Nature | NEWS & VIEWS, Cell Metabolism: Autophagy transcribed, Nature. 2014 Dec 4;516(7529):40-1. doi: 10.1038/nature13939. Epub 2014 Nov 12.
Comment in Nature Reviews Endocrinology | RESEARCH HIGHLIGHTS, Metabolism: Nutrient-sensing and autophagic genes in fed and fasted states, Nat Rev Endo. 2015 Feb; 11(2):66
8. Mamrosh JM, Lee JM, Wagner M, Stambrook PJ, Whitby RJ, Sifers RN, Wu SP, Tsai MJ, DeMayo FJ, and Moore DD. Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. Elife. 2014 Apr 15; 3:e01694.
9. Park YJ, Kim SC, Kim J, Anakk S, Lee JM, Tseng HT, Yechoor V, Park J, Choi JS, Jang HC, Lee KU, Novak CM, Moore DD, and Lee YK. Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. J Lipid Res. 2011 Dec;52(12):2234-44. Epub 2011 Sep 23.
10. Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, and Moore DD. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 2011 May 25;474(7352):506-10.
Comment in Nature | NEWS & VIEWS, Metabolism: A lipid for fat disorders, Nature. 2011 Jun 23;474(7352):455-6.
Comment in Nature Reviews Drug Discovery | RESEARCH HIGHLIGHTS, Obesity and diabetes: An antidiabetic phospholipid, Nat Rev Drug Discov. 2011 Jul 1;10(7):493
Comment in Journal of Hepatology | Commentary on A lipid to treat non-alcoholic fatty liver disease - The dawn of 'lipo-rehabilitation'?, J Hepatol. 2011 Oct 18.
Comment In Nature Medicine | NEWS, Notable advances 2011, Metabolism, Bile thumper, Nature Medicine. 2011 Dec 06;17(12):1540-1541.
11. Lee EH, Song DW, Lee JM, Meissner G, Allen PD, and Kim do H. Occurrence of atypical Ca2+ transients in triadin-binding deficient-RYR1 mutants. Biochem Biophys Res Commun. 2006 Dec 29;351(4):909-14.
12. Lee JM, Rho SH, Shin DW, Cho C, Park WJ, Eom SH, Ma J, and Kim DH. Negatively charged amino acids within the intraluminal loop of ryanodine receptor are involved in the interaction with triadin. J Biol Chem. 2004 Feb 20;279(8):6994-7000.
13. Shin DW, Pan Z, Kim EK, Lee JM, Bhat MB, Parness J, Kim DH, and Ma J. A retrograde signal from calsequestrin for the regulation of store-operated Ca2+ entry in skeletal muscle. J Biol Chem. 2003 Jan 31;278(5):3286-92.
Working model of the antidiabetic effect of DLPC & LRH-1.
Activation of the nuclear receptor LRH-1 by DLPC sets up a positive regulatory loop in which decreased ADD1 / SREBP-1c expression and subsequent decreased steatosis results in increased hepatic insulin sensitivity. This leads to a decrease in serum insulin levels and a further decrease in SERBP-1c mRNA and fatty liver that continues the positive cycle. This is essentially the opposite of the lipogenic vicious cycle to insulin resistance proposed by McGarry. (Modified from Lee et al., Nature. 2011. 474:506-10.; Musille et al., Nat Struct Mol Biol. 2012. 19:532-7)
Working model for the mechanism of LRH-1 requirement in ER stress resolution. A novel ER stress resolution pathway initiated by the nuclear receptor LRH-1 is independent of known unfolded protein response (UPR) pathways. This novel LRH-1-PLK3-ATF2 pathwy represents a core pathway that is required for hepatic ER stress resolution. (Modified from Mamrosh et al., Elife. 2014;3:e01694.)
Working model for autophagy regulation by nutrient-sensing NR.
Transcriptionally activating or suppressive nutrient-sensing NR, PPARα or FXR, respectively, coordinates autophagy in liver. PPARα or FXR competes each other for binding to response elements found in the regulatory regions of autophagy-related genes. Transcriptional coordination of autophagy-related genes contributes to long-term regulation of autophagy. (Modified from Lee et al., Nature. 2014. 516:122-5.)
Contact Info.
Jae Man Lee, Ph.D.
Assistant Professor
Department of Biochemistry & Cell Biology
School of Medicine
Kyungpook National University
680 Gukchaebosang-ro, Jung-gu
Daegu 41944, Republic of Korea
E-mail: jaemanlee@knu.ac.kr
Phone: +82-53-420-4826
Website: http://jmlee0613.wix.com/nrdl-knumed
